RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research[1].
Molecular Weight:
2308.61
Purity:
98.13
CAS Number:
[1541177-35-8]
Formula:
C98H166N30O32S
Target:
Apoptosis,NOD-like Receptor (NLR),p38 MAPK
Application Notes:
MCE Product type: Peptides
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