IL-1 alpha, found in non-hematopoietic cells, connects innate and adaptive immunity. Binding to IL1R1, it activates signaling pathways involving MYD88, IRAK1, and IRAK4, leading to NF-kappa-B and MAPK pathway activation. Released during cell death, IL-1 alpha induces inflammation, senses DNA damage, and interacts with TMED10, IL1R1, and S100A13 for secretion and plasma membrane translocation. IL-1 alpha Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-1 alpha protein, expressed by HEK293 , with C-His labeled tag.
Molecular Weight:
Approximately 25-35 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Purity:
95.00
Formula:
101926546(Gene_ID)P79340 (S113-A271)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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