GDF-15 Protein, a key regulator of food intake and energy balance, binds to its receptor GFRAL, activating neurons in the brainstem and forming an emergency circuit for feeding responses during stress. Additionally, GDF-15 inhibits growth hormone signaling on hepatocytes, existing as a disulfide-linked homodimer. Interacting with GFRAL, it acts as a ligand, mediating GDF15 internalization and cellular signaling through RET. GDF-15 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived GDF-15 protein, expressed by E. coli , with N-His labeled tag.
Molecular Weight:
Approximately 15-18 kDa,based on SDS-PAGE under reducing conditions.
Formula:
102117226(Gene_ID)G7PWZ3 (R193-V308)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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