Bone morphogenetic protein 7 (BMP-7) is a polymorphic ligand protein belonging to the TGF-beta family. BMP-7 is involved in regulating the proliferation, invasion and migration of cancer cells and is associated with a variety of human tumors[1]. BMP-7 binds ALK2 or ACVR2A/BMPR2 excitation signal, which is terminated by SMADs regulation[2]. BMP-7 is involved in the BMP-7-SMad1/5/9 signaling pathway, which is associated with the epithelial-mesenchymal transition (EMT) process[1]. BMP-7 also eliminates vascular inflammation, maintains vascular integrity[3], reduces vascular calcification, and stimulates in situ phosphate ossification deposition[4].
Molecular Weight:
Approximately 18 kDa, based on SDS-PAGE under reducing conditions.
Purity:
95
Formula:
655(Gene_ID)P18075 (S293-H431)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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