HNF 4 alpha, a nuclear transcription factor, forms homodimers to bind DNA. It regulates gene expression, including hepatocyte nuclear factor 1 alpha, impacting hepatic genes. Its involvement extends to liver, kidney, and intestinal development. Mutations associate with autosomal dominant non-insulin-dependent diabetes mellitus type I. The gene exhibits biased expression in the duodenum (RPKM 37.7) and colon (RPKM 32.8), among other tissues. HNF4A Protein, Human (HEK293, His) is the recombinant human-derived HNF 4 alpha, expressed by HEK293 , with C-10*His labeled tag.
Molecular Weight:
Approximately 80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
