MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation. MDM2 Protein, Human (His) is the recombinant human-derived MDM2 protein, expressed by E. coli , with N-6*His labeled tag.
Molecular Weight:
Approximately 13.1 KDa
Purity:
99
Formula:
4193(Gene_ID)Q00987 (S17-N111)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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