MGMT Protein crucially defends against O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA, using a suicide reaction to repair methylated nucleobases. It stoichiometrically transfers the methyl group to a cysteine residue, but this process irreversibly inactivates MGMT. The sacrificial nature of MGMTs function emphasizes its commitment to safeguarding cellular DNA integrity at the expense of its own activity. MGMT Protein, Human (His) is the recombinant human-derived MGMT protein, expressed by E. coli , with N-6*His labeled tag.
Molecular Weight:
Approximately 24.0-26.0 kDa
Purity:
98
Formula:
4255(Gene_ID)P16455 (M1-N207)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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