IFN-alpha/beta R2 protein and IFNAR1 together constitute the heterodimeric receptor of type I interferon and initiate the JAK-STAT signaling cascade. Upon binding of type I interferons, IFNAR1 and IFNAR2 activate related Janus kinases (TYK2 and JAK1) in proximity, resulting in cross-phosphorylation. IFN-alpha/beta R2 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived IFN-alpha/beta R2 protein, expressed by HEK293, with C-Avi and C-His labeled tag.
Molecular Weight:
Approximately 50-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formula:
15976(Gene_ID)O35664-1 (S22-A242)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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