CTLA-4 Protein, a pivotal inhibitory receptor, is a primary negative modulator of T-cell responses in immune regulation. Its distinctive property lies in significantly higher affinity for B7 ligands (CD80/CD86) than the stimulatory coreceptor CD28. Outcompeting CD28 for ligand engagement, CTLA-4 exerts a suppressive influence on T-cell activation, mitigating excessive immune responses in the intricate landscape of immune regulation. CTLA-4 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived CTLA-4 protein, expressed by HEK293, with C-hFc labeled tag.
Molecular Weight:
Approximately 42-50 kDa,based on SDS-PAGE under reducing conditions,80-100 kDa,based on SDS-PAGE under non-reduced conditions,due to the glycosylation.
Formula:
/(Gene_ID)G7PL88 (A37-S160)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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