IL-4 Protein is an endogenous agonist of IL-4 receptor (IL-4R), which works through the JAK1/JAK3-STAT6 signaling pathway. It can cooperate with SCF to promote the proliferation of human intestinal mast cells (ED50=100 pg/mL) and enhance the release of mediators such as histamine mediated by IgE receptor. IL-4 Protein can inhibit the production of IL-8 by human monocytes and regulate the secretion of endothelial cell factors. It is mainly used for IL-4R targeted therapy research of tumors (such as malignant pleural mesothelioma) and allergic diseases. IL-4 Protein, Human is a recombinant protein of human IL-4, expressed by E. coli, with tag free.
Molecular Weight:
Approximately 13-15 kDa, based on SDS-PAGE under reducing conditions.
Purity:
98.00
Formula:
3565(Gene_ID)P05112-1 (H25-S153)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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