FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293, with C-hFc labeled tag.
Molecular Weight:
Approximately 57-65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Formula:
14275(Gene_ID)P35846 (T25-S232)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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