IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, Fc) is the recombinant human-derived IGF-I R protein, expressed by HEK293, with C-hFc labeled tag.
Molecular Weight:
Approximately 70-75 kDa and 105-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Formula:
3480(Gene_ID)P08069 (E31-N932)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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