IFNAR1, one of the subunit of IFN-alpha/beta receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Human (HEK293, His) is a recombinant human IFNAR1 (K28-K436) with C-terminal 6*His tag, which is produced in HEK293 cells.
Molecular Weight:
70-120 kDa
Purity:
98
Formula:
3454(Gene_ID)P17181-1 (K28-K436)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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