IFN-gamma is a cytokine. IFN-gamma can exert anticancer effects by activating p53 and p21, leading to cell cycle arrest, and/or by activating IRF-1 and Caspase-1, leading to pyroptosis, and by activating IRF-1, Caspase-8, cytochrome c release from mitochondria, Caspase cascades, and inhibiting PARP, leading to intrinsic apoptotic signaling. IFN-gamma can induce fusion of human monocytes to form multinucleated giant cells and activate monocytes, increasing their ability to produce hydrogen peroxide, acid phosphatase, and plasminogen activator. IFN-gamma can enhance the sensitivity of human macrophages to lysis mediated by extracellular ATP. IFN-gamma upregulates the transcription and expression of TNF-alpha by inhibiting the expression of IL-10 and relieving the feedback inhibition of IL-10 on TNF-alpha. IFN-gamma Protein, Human (HEK293) is a recombinant interferon-gamma protein expressed in HEK293 cells without a tag.
Molecular Weight:
Approximately 20-24 kDa & 16-17 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Purity:
98
Formula:
3458(Gene_ID)P01579 (Q24-Q166)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
* VAT and and shipping costs not included. Errors and price changes excepted
