IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with tag free.
Molecular Weight:
Approximately 16-20 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Purity:
98
Formula:
3586(Gene_ID)P22301 (S19-N178)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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