SENP7, a versatile protease, positively regulates the cGAS-STING pathway by desumoylating CGAS, enhancing its DNA-binding and activation. Specific to SUMO2 and SUMO3, SENP7 proficiently deconjugates poly-SUMO2 and poly-SUMO3 chains, dynamically regulating protein sumoylation. While less efficient in processing full-length SUMO proteins, SENP7s role in modulating the cGAS-STING pathway highlights its importance in innate immune responses. SENP7 Protein, Human is the recombinant human-derived SENP7 protein, expressed by E. coli , with tag free.
Molecular Weight:
Approximately 22 kDa,based on SDS-PAGE under reducing conditions.
Formula:
57337(Gene_ID)Q9BQF6-1 (M695-A864)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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