The SMAD3 protein acts as a receptor-regulated SMAD (R-SMAD), transducing signals from TGF-beta and activin type 1 receptor kinase. After being activated by antigen-presenting cells, SMAD3 binds to the TRE element in the gene promoter and forms a complex with SMAD4 to activate transcription. SMAD3 Protein, Human/Mouse/Rat (Flag-His) is the recombinant human-derived SMAD3 protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.
Molecular Weight:
Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions.
