UBE2A cooperates with the E3 enzyme BRE1 to promote the attachment of ubiquitin to proteins, specifically histone H2B at Lys-120, forming H2BK120ub1. This modification serves as a tag for transcriptional activation, RNA polymerase II elongation, telomeric silencing, and is critical for the formation of H3K4me and H3K79me. UBE2A Protein, Human (GST-His) is the recombinant human-derived UBE2A protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
Molecular Weight:
Approximately 45 kDa, based on SDS-PAGE under reducing conditions.
Purity:
95
Formula:
7319(Gene_ID)P49459-1 (M1-C152)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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