RANK (TNFRSF11A) is a receptor activator of nuclear factor kappaB (NF-kappaB), which is involved in bone metabolism and immune system function. RANK is mainly expressed by osteoblasts/stromal cells, and is associated with the formation of giant cell tumor of bone (GCTBs) [1]. RANK combined with RANKL ligand activated the RANKL/RANK/ OPG system to regulate bone resorption [2]. RANKL/RANK is also a regulator of dendritic cell (DC)-T cell interaction, which is associated with mammary epithelial formation and central nervous system thermoregulation in lactating female [3][4]. RANK/TNFRSF11A Protein, Human (His) produced by HEK293 cells with N-terminal His-tag.
Molecular Weight:
Approximately 21 kDa, based on SDS-PAGE under reducing conditions.
Purity:
96.00
Formula:
8792(Gene_ID)Q9Y6Q6 (L28-K202)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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