FGF-12, vital for nervous system development, positively regulates voltage-gated sodium channels, particularly SCN8A, enhancing neuronal excitability. It achieves this by elevating the voltage dependence of SCN8A fast inactivation. FGF-12 interacts specifically with the C-terminal region of SCN9A. FGF-12 Protein, Human (181a.a, His) is the recombinant human-derived FGF-12 protein, expressed by E. coli , with N-6*His labeled tag.
Molecular Weight:
Approximately 23 kDa, based on SDS-PAGE under reducing conditions.
Purity:
95
Formula:
2257(Gene_ID)P61328-2 (M1-T181)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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