LIGHT/TNFSF14, Human (HEK293, hFC-Myc)

Product Overview

• Article Name: LIGHT/TNFSF14, Human (HEK293, hFC-Myc)
• Biozol Catalog Number: MCE-HY-P72033
• Supplier Catalog Number: HY-P72033
• Alternative Catalog Number: MCE-HY-P72033-5UG,MCE-HY-P72033-50UG,MCE-HY-P72033-10UG
• Manufacturer: MedchemExpress
• Category: Proteine/Peptide
• Alternative Names: LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc),Human,HEK293

Product Description

LIGHT/TNFSF14 protein (CD258, TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNgamma, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTbetaR-NIK-p52 NF-kappaB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc) is the extracellular part (D74-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal hFc- and Myc-tag.

Product Properties

• Molecular Weight: Approximately 47 kDa, based on SDS-PAGE under reducing conditions.
• Purity: 90
• Formula: 8740(Gene_ID)O43557 (D74-V240)(Accession)

Application Notes

• Application Notes: MCE Product type: Recombinant Proteins