ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag.
Molecular Weight:
Approximatel 57 (Mature form)&20 kDa (Propeptide), on SDS-PAGE under reducing conditions.
Purity:
97.10
Formula:
57027(Gene_ID)Q9Z1K9 (P18-D563)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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