Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TGFbeta family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification[1]. BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes[5]. BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism[6]. Zebrafish BMP-2 Protein has a length of 386 a.a., BMP-2 Protein, Zebrafish is 105 a.a. (Q272-R386), expressed in E. coli cells with tag free.
Molecular Weight:
Approximately 13 kDa, based on SDS-PAGE under reducing conditions.
Purity:
97.20
Formula:
/(Gene_ID)B3DI86 (Q272-R386)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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