Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1]. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death[2]. TNF alpha stimulates NF-kappaB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-alpha MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3]. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4]. TNF-alpha/TNFSF2 Protein, Bovine is produced in E. coli.
Molecular Weight:
Approximately 17 kDa, based on SDS-PAGE under reducing conditions.
Purity:
95.00
Formula:
280943(Gene_ID)Q06599-1 (L78-L234)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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