IL-33 Protein activates NF-kappa-B and MAPK signaling, inducing Th2 cell maturation and cytokine secretion. It activates mast cells, basophils, eosinophils, and natural killer cells, acting as a chemoattractant for Th2 cells. IL-33 preserves Krebs cycle integrity, reducing reactive oxygen species production. In quiescent endothelial cells, IL-33 acts as a transcriptional repressor, but is lost upon angiogenic or pro-inflammatory activation. IL-33 Protein, Canine is the recombinant canine-derived IL-33 protein, expressed by E. coli , with N-Met labeled tag.
Molecular Weight:
Approximately 19 kDa, based on SDS-PAGE under reducing conditions.
Purity:
95.50
Formula:
403810(Gene_ID)O97863 (S110-S263)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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