The PCSK9 protein regulates cholesterol levels by interacting with LDLR, VLDLR, LRP1/APOER, and LRP8/APOER2. It promotes their degradation and inhibits their recycling, leading to enhanced LDLR degradation. PCSK9 also affects APOB degradation, BACE1 intermediates, ENaC surface expression, and neuronal apoptosis via LRP8/APOER2. PCSK9 Protein, Rat (HEK293, His) is the recombinant rat-derived PCSK9 protein, expressed by HEK293 , with C-6*His labeled tag.
Molecular Weight:
Approximately 17.26 & 60.16kDa
Purity:
95
Formula:
298296(Gene_ID)P59996 (Q31-Q691)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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