TIE-2 Protein, Mouse (HEK293, His) belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Ang1 bridges TIE-2 at cell-cell contacts, resulting in trans-association of TIE-2 in the presence of cell-cell contacts. TIE-2 activation promotes vessel assembly and maturation by mediating survival signals for EC and regulating the recruitment of pericytes. TIE-2 maintains the vascular integrity of mature vessels by enhancing endothelial barrier function and inhibiting apoptosis of endothelial cells[1][2][3]. TIE-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TIE-2 protein, expressed by HEK293 , with C-His labeled tag.
Molecular Weight:
Approximately 91-120 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Purity:
98.00
Formula:
21687(Gene_ID)B1AWS8 (A23-K744)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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