HTRA2/OMI, a serine protease, crucially induces cell death via multiple mechanisms.It directly inhibits BIRC proteins, intensifying caspase activity, and can also induce cell death through a BIRC-independent, caspase-independent pathway, relying on its serine protease activity.Additionally, during apoptosis, it cleaves THAP5, promoting its degradation.Notably, isoform 2 lacks apparent proteolytic activity.HTRA2/OMI Protein, Human (His) is the recombinant human-derived HTRA2/OMI protein, expressed by E.coli , with C-His labeled tag.
Molecular Weight:
Approximately 36.5 kDa
Purity:
91.80
Formula:
27429(Gene_ID)O43464 (A134-E458)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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