IL-18 is a pleiotropic proinflammatory cytokine that is involved in induction of inflammatory mediators, regulation of the cytotoxic activity of NK cells and T cells, and differentiation and activation of both Th1 and Th2 cells. IL-18 signals through its specific cell surface receptor IL-18R, which comprises two subunits: IL-18Ralpha and IL-18R beta. IL-18 forms a signalling complex with the IL-18 receptor alpha (Ralpha) and beta (Rbeta) chains at the plasma membrane, which induces multiple inflammatory cytokines[2]. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kbeta- inducing kinase, with subsequent activation of NF- kbeta[3].IL-18R betaknockdown inhibits IL-18 driven tumor cell metastasis in C57/BL6 mice[4]. IL-18RAP Protein, Mouse (sf9, His) is a recombinant protein with a His label and is produced by Sf9 insect cells.
Molecular Weight:
Approximately 44 kDa, based on SDS-PAGE under reducing conditions.
Formula:
16174(Gene_ID)Q9Z2B1 (F20-E356)(Accession)
Application Notes:
Recombinant Proteins
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