ITCH/AIP4 protein is an E3 ubiquitin protein ligase that catalyzes the conjugation of ''Lys-29, ''Lys-48 and ''Lys-63 linked ubiquitin, affecting inflammatory signaling pathways. It forms a ubiquitin editing complex that promotes RIPK1 degradation and terminates TNF- or LPS-mediated NFKB1 activation. ITCH/AIP4 Protein, Human is the recombinant human-derived ITCH/AIP4 protein, expressed by E. coli , with tag free.
