The SMPD1 protein converts sphingomyelin to ceramide through two enzymatic forms, one targeted to endolysosomes and the other released extracellularly.Lysosomal exocytosis becomes a significant source of the secretory form during stress responses.SMPD1 also exports cholesterol from intraendolysosomal membranes and exhibits phospholipase C activities.Its role in stress-induced apoptosis modulation is mediated through ceramide production.SMPD1 Protein, Mouse (sf9, C-His) is the recombinant mouse-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Molecular Weight:
Approximately 68-71 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Purity:
96
Formula:
20597(Gene_ID)Q04519 (L45-L626)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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