FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of beta-catenin through the EGFR/AKT/GSK3beta axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, Fc) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag.
Molecular Weight:
Approximately 50.7 kDa.
Formula:
609612(Gene_ID)XP_851993.1 (R25-M228)(Accession)
Application Notes:
Recombinant Proteins
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