FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of beta-catenin through the EGFR/AKT/GSK3beta axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, His) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
Molecular Weight:
Approximately 27-40 kDa due to the glycosylation.
Purity:
96.00
Formula:
609612(Gene_ID)XP_851993.1 (R25-M228)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
* VAT and and shipping costs not included. Errors and price changes excepted