BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence.This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment.BACE1s cleavage activity extends to CHL1, demonstrating its versatility in substrate processing.BACE1 Protein, Human (HEK293, Fc) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with C-hFc labeled tag.
Molecular Weight:
Approximately 100-105 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formula:
23621(Gene_ID)P56817-1 (T22-T457)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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