CD28 Protein plays a pivotal role in T-cell activation, promoting cell proliferation, cytokine production, and T-cell survival. Upon ligation with TCR/CD3 and CD40L costimulation, CD28 enhances the production of IL4 and IL10 in T-cells, contributing to immune response modulation. Additionally, isoform 3 of CD28 facilitates CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. The protein forms homodimers through disulfide linkages and interacts with various molecules. CD28 Protein, Canine (HEK293, His) is the recombinant canine-derived CD28 protein, expressed by HEK293 , with C-His labeled tag.
Molecular Weight:
40-60 kDa
Purity:
95
Formula:
403646(Gene_ID)Q9GKP3 (T18-P153)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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