DKK-3 protein antagonizes canonical Wnt signaling by blocking LRP5/6-Wnt interactions and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization.In vertebrate development, DKK-3, together with other DKKs, critically inhibits Wnt-regulated processes such as axial patterning, limb development, somitogenesis, and eye formation.DKK-3 Protein, Human (HEK293, His) is the recombinant human-derived DKK-3 protein, expressed by HEK293 , with C-6*His labeled tag.
Molecular Weight:
Approximately 654-73 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Purity:
95
Formula:
27122(Gene_ID)Q9UBP4 (A22-I350)(Accession)
Application Notes:
Recombinant Proteins
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