AITRL/TNFSF18 Trimer, Human (HEK293, His-Flag)

Product Overview

• Article Name: AITRL/TNFSF18 Trimer, Human (HEK293, His-Flag)
• Biozol Catalog Number: MCE-HY-P78448
• Supplier Catalog Number: HY-P78448
• Alternative Catalog Number: MCE-HY-P78448-20UG,MCE-HY-P78448-50UG
• Manufacturer: MedchemExpress
• Category: Proteine/Peptide
• Alternative Names: AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag),Human,HEK293

Product Description

AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human AITRL (Q72-S199) trimer with N-terminal His and Flag tag, which is expressed in HEK293.

Product Properties

• Molecular Weight: Approximately 50-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
• Purity: 95
• Formula: 8995(Gene_ID)Q9UNG2 (Q50-S177)(Accession)

Application Notes

• Application Notes: Recombinant Proteins