LIGHT/TNFSF14 Trimer, Human (HEK293, His-Flag) Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-P78477
Supplier Catalog Number:
HY-P78477
Alternative Catalog Number:
MCE-HY-P78477-1UNIT
Manufacturer:
MedchemExpress
Category:
Proteine/Peptide
Alternative Names:
LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag),Human,HEK293
LIGHT/TNFSF14 protein (CD258, TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNgamma, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTbetaR-NIK-p52 NF-kappaB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag) is the extracellular part (S89-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal His- and Flag-tag.
Molecular Weight:
Approximately 53-140 kDa, based on SDS-PAGE under non-reducing conditions, due to the glycosylation.
Formula:
8740(Gene_ID)O43557 (S89-V240)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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