IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway[1][2]. IL-6R alpha, Mouse consists of 460 amino acids (M1-R460) with two fibronectin type-III-like domains contained in the N-terminal part (109-214 a.a, 215-313 a.a). Soluble IL-6R (sIL-6R) can be detected in the cerebrospinal fluid, conducts trans signaling by binding IL-6 and dimerized gp130, and exhibits a immune tissue expression property. IL-6R alpha, Mouse (L20-E357) is soluble form and produced in HEK293 cells with a C-Terminal His- and Avi-tag.
Molecular Weight:
45-66 kDa
Formula:
16194(Gene_ID)P22272 (L20-E357)(Accession)
Application Notes:
Recombinant Proteins
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