BMP-3 Protein, a TGF-beta superfamily member, crucially influences early skeletal formation and acts as a bone density negative regulator. It counteracts osteogenic BMPs, hindering osteoprogenitor differentiation. BMP-3 initiates signaling via ACVR2B, activating SMAD2-dependent and SMAD-independent pathways, including TAK1 and JNK. Structurally, it forms homodimers with disulfide bonds, interacting with ACVR2B to regulate functions. BMP-3 Protein, Human is the recombinant human-derived BMP-3 protein, expressed by E. coli , with tag free.
Molecular Weight:
Approximately 12 kDa, based on SDS-PAGE under reducing conditions.
Purity:
98.00
Formula:
651(Gene_ID)P12645 (Q363-R472)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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