Tegoprubart (AT-1501) acts as a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. It suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart exhibits acceptable safety and tolerability in kidney transplant recipients, preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection[1].
Molecular Weight:
(145.56 kDa)
Purity:
99.90
CAS Number:
[2628092-47-5]
Target:
TNF Receptor
Application Notes:
MCE Product type: Inhibitory Antibodies
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