Mipletamig (APVO-436) is a bispecific CD123 x CD3 monoclonal antibody. Mipletamig simultaneously binds to both CD3-expressing T cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. Mipletamig can be used for the study of acute myeloid leukemia (AML)[1].
Molecular Weight:
(161.454 kDa)
Purity:
99
CAS Number:
[2839556-21-5]
Target:
CD3,Interleukin Related
Application Notes:
MCE Product type: Inhibitory Antibodies
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