Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-kappa_G1-lambda2) subtype that targets EGFR/MET. Tilatamig conjugates with the Top1 inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC)[1].
Molecular Weight:
(144.77 kDa)
Purity:
99.99
CAS Number:
[2868265-50-1]
Target:
ADC Antibody,EGFR
Application Notes:
MCE Product type: Inhibitory Antibodies
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