Ficerafusp alfa is a bispecific antibody targeting EGFR and TGFbeta, with a Kd of 2.58 nM against EGFR and a Kd of 61.3 nM against TGFbeta1. Ficerafusp alfa binds to EGFR, inhibits EGFR phosphorylation, blocks EGF-dependent cell proliferation, and mediates antibody-dependent cellular cytotoxicity against EGFR-positive tumor cells. Ficerafusp alfa sequesters TGFbeta via its TGFbetaRII ECD domain, neutralizes the activity of TGFbeta and TGFbeta1, and blocks TGFbeta-dependent processes, including epithelial-mesenchymal transition, cell invasion, and differentiation of inducible regulatory T cells. Ficerafusp alfa is applicable to research related to head and neck squamous cell carcinoma, advanced solid tumors, squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer[1][2][3].
Molecular Weight:
(178.105 kDa)
Purity:
99.71
CAS Number:
[2764727-44-6]
Target:
EGFR
Application Notes:
MCE Product type: Inhibitory Antibodies
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