1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL)[1][2][3].
CAS Number:
[791073-97-7]
Target:
Apoptosis,JNK,MHC,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Inhibitory Antibodies
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