REGN7999 is a monoclonal antibody that inhibits TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a beta-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in beta-thalassemia[1][2].
Target:
Ser/Thr Protease
Application Notes:
MCE Product type: Inhibitory Antibodies
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