Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular alpha-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].
Molecular Weight:
(145.671 kDa)
Purity:
99.46
CAS Number:
[1036734-93-6]
Target:
IGF-1R,TSH Receptor
Application Notes:
MCE Product type: Inhibitory Antibodies
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