MEDI4212 is a humanized IgG1lambda monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcepsilonRI, such as calcium signaling, beta-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC50 of 8 nM. MEDI4212 can be used severe asthma research[1].
Target:
Fc Receptor (FcR)
Application Notes:
MCE Product type: Inhibitory Antibodies
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