SAR228810 is a humanized IgG4 monoclonal antibody inhibitor targeting amyloid beta (Abeta) with a KD? of ?0.43 ?nM for protofibrillar Abeta over monomeric Abeta. SAR228810 significantly inhibits the brain amyloid plaque formation and oligomer-induced synaptic dysfunction and neurite loss. SAR228810 has significant protection against Abeta-mediated neuritotoxicity. MINT1526A can be used for Alzheimers disease imaging and immunotherapy research[1][2].
Target:
Amyloid-beta
Application Notes:
MCE Product type: Inhibitory Antibodies
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