VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research[1].
Molecular Weight:
(145.72 kDa)
Purity:
99.9
Target:
Calcium Channel,Syk,TREM receptor
Application Notes:
MCE Product type: Inhibitory Antibodies
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